해외 연구시약 수입·전문 취급 · 국내 대리점 관련 문의

CDKN1B — 카탈로그 16건

Gene CDKN1B NCBI Gene 1027
취급 제조사 5곳
CusabioMyBioSourceBiosynthCloud-CloneELK Biotechnology
국내 소싱 가능
16건

유전자 개요

CDKN1B는 사이클린 의존성 키나아제 저해제(cyclin-dependent kinase inhibitor)를 암호화하며, CDK 저해제인 CDKN1A/p21과 제한적인 유사성을 공유한다. 암호화된 단백질은 사이클린 E-CDK2 또는 사이클린 D-CDK4 복합체에 결합하여 활성화를 억제함으로써 G1기에서 세포 주기(cell cycle) 진행을 조절한다. CDK 의존적 인산화(phosphorylation)와 이후 SCF 복합체에 의한 유비퀴틴화(ubiquitination)에 의해 촉발되는 이 단백질의 분해는 세포가 정지기에서 증식 상태로 전환하는 데 필요하다. 이 유전자의 돌연변이는 다발성 내분비 신생물 형태 IV(MEN4)와 관련이 있다.

AKT phosphorylates targets in the cytosolConstitutive Signaling by AKT1 E17K in CancerCyclin A:Cdk2-associated events at S phase entryCyclin D associated events in G1Cyclin E associated events during G1/S transition DNA Damage/Telomere Stress Induced SenescenceDefective binding of RB1 mutants to E2F1,(E2F2, E2F3)Estrogen-dependent nuclear events downstream of ESR-membrane signalingFLT3 SignalingFOXO-mediated transcription of cell cycle genes
multiple endocrine neoplasia type 4prostate carcinomahereditary neoplastic syndromeInherited cancer-predisposing syndromethyroid carcinomaneurodegenerative diseasebody heightlean body mass
데이터 출처 · 근거

체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.

견적제조사Cat NoMfr No제품명HostClonalityReactivityApplicationSize
CusabioT094-109388-01CSB-RA005087A0HUCDKN1B Recombinant Monoclonal AntibodyRabbitMonoclonalHuman, MouseELISA, WB, IHC, IF50μl, 100μl
MyBioSourceR247-212474-01MBS9601895p27 Kip1 (CDKN1B), Polyclonal AntibodyRabbitPolyclonalHuman, Mouse, RatWB; IF; ICC; ELISA0.1 mL
BiosynthF502-128895-0170R-33639CDKN1B antibodyRabbitPolyclonalCDKN1B antibody detects endogenous levels of total CDKN1B protein; Cross: MouseWB, ELISA0.1 mg
BiosynthF502-128894-0170R-33638CDKN1B antibody (Thr198)RabbitPolyclonalCDKN1B antibody detects endogenous levels of CDKN1B only when phosphorylated at threonine 198WB, ELISA0.1 mg
BiosynthF502-128892-0170R-33636CDKN1B antibody (Thr157)RabbitPolyclonalCDKN1B antibody detects endogenous levels of CDKN1B only when phosphorylated at threonine 157IHC, ELISA0.1 mg
BiosynthF502-115392-0170R-10482CDKN1B antibodyRabbitPolyclonalHuman; Cross: HumanWB100 ul
BiosynthF502-103568-0110R-2185CDKN1B antibodyMouseMonoclonalHuman; Cross: HumanELISA, WB100 ul
BiosynthF502-128893-0170R-33637CDKN1B antibodyRabbitPolyclonalCDKN1B antibody detects endogenous levels of total CDKN1B proteinIHC, ELISA0.1 mg
Cloud-CloneT813-125918-01PAE625Mu01Polyclonal Antibody to Cyclin Dependent Kinase Inhibitor 1B (CDKN1B)RabbitPolyclonalMurineWB100µl
Cloud-CloneT813-125917-01PAE625Hu01Polyclonal Antibody to Cyclin Dependent Kinase Inhibitor 1B (CDKN1B)RabbitPolyclonalHumanWB; IHC100µl
MyBioSourceR247-156589-01MBS532869CDKN1B, Monoclonal AntibodyMouseMonoclonalHumanELISA; WB0.1 mL
MyBioSourceR247-190912-01MBS8225797p27 Kip1 (CDKN1B), Polyclonal AntibodyRabbitPolyclonalHuman, Mouse, Bovine, DogWB; IHC; IF; ICC0.03 mL
ELK BiotechnologyT376-116560-01ES1378p27 (phospho Ser10) rabbit pAbRabbitPolyclonalHuman;Mouse;RatWB;ELISA50μL
ELK BiotechnologyT376-120069-01ES4448p27 (phospho Thr198) rabbit pAbRabbitPolyclonalHuman;Rat;Mouse;WB;ELISA50μL

관련 표적

같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.

CDKN1A p53-Dependent G1 DNA Damage Response CDK2 PTK6 Regulates Cell Cycle CCNE1 PTK6 Regulates Cell Cycle CCND1 PTK6 Regulates Cell Cycle AKT1 AKT phosphorylates targets in the cytosol AKT2 AKT phosphorylates targets in the cytosol AKT3 AKT phosphorylates targets in the cytosol CDK4 PTK6 Regulates Cell Cycle
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