CDK1 — 카탈로그 25건
Gene CDK1
NCBI Gene 983
국내 소싱 가능
25건
유전자 개요
이 유전자는 세린/트레오닌 단백질 키나아제(Ser/Thr protein kinase) 계열에 속하는 단백질을 암호화한다. 이 단백질은 G2/M기 세포 주기(cell cycle) 전환에 필수적인 M기 촉진 인자(M-phase promoting factor, MPF)로 알려진 고도로 보존된 단백질 키나아제 복합체의 촉매 소단위체이다. 유사분열 시클린(Mitotic cyclins)은 이 단백질과 안정적으로 결합하여 조절 소단위체로 기능한다. 이 단백질의 키나아제 활성은 세포 주기를 통한 시클린 축적 및 분해에 의해 조절된다. 또한, 이 단백질의 인산화(phosphorylation) 및 탈인산화는 세포 주기 조절에서 중요한 조절 역할을 수행한다. 이 유전자에 대해 다른 아이소폼을 암호화하는 대체 스플라이싱 전사체 변이체(alternatively spliced transcript variants)가 발견되었다.
APC/C:Cdc20 mediated degradation of Cyclin BAURKA Activation by TPX2Activation of NIMA Kinases NEK9, NEK6, NEK7Anchoring of the basal body to the plasma membraneCdc20:Phospho-APC/C mediated degradation of Cyclin AChk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexCondensation of Prometaphase ChromosomesCondensation of Prophase ChromosomesCyclin A/B1/B2 associated events during G2/M transitionDepolymerization of the Nuclear Lamina
neurodegenerative diseaseAlzheimer diseaseParkinson diseaselysosomal storage diseasemultiple sclerosisheel bone mineral densityserum gamma-glutamyl transferase measurementprostatitis
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition. · Nature (2022)Inhibition of CDK1 Overcomes Oxaliplatin Resistance by Regulating ACSL4-mediated Ferroptosis in Colorectal Cancer. · Adv Sci (Weinh) (2023)CDK1 Interacts with Sox2 and Promotes Tumor Initiation in Human Melanoma. · Cancer Res (2018)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| Cusabio | T094-107569-01 | CSB-PA361848LA01HU | CDK1 Antibody | Rabbit | Polyclonal | Human | ELISA, IHC | 50μg, 100μg | |
| Cusabio | T094-104963-01 | CSB-MA085459 | CDK1 Monoclonal Antibody | Mouse | Monoclonal | Human,Dog,Rat,Mouse | ELISA,WB,ICC | 100μl | |
| Biosynth | F502-102738-01 | 10R-11233 | CDK1 antibody | Mouse | Monoclonal | Human; Cross: Mouse, Rat, Monkey | WB, IHC, IF, ELISA | 0.1 mg | |
| Biosynth | F502-102742-01 | 10R-11242 | CDK1 antibody | Mouse | Monoclonal | Human; Cross: Mouse, Rat, Monkey | WB, ELISA | 0.1 mg | |
| Biosynth | F502-133879-01 | 70R-49522 | CDK1/2/3 antibody | Rabbit | Polyclonal | Recognizes endogenous levels of CDK1/2/3 protein; Cross: Mouse, Rat, Bovine, Chicken, Monkey | WB, IF, ICC | 100 ul | |
| Biosynth | F502-131344-01 | 70R-36289 | CDK1 antibody | Rabbit | Polyclonal | CDK1 antibody detects endogenous levels of total CDK1 protein; Cross: Mouse, Rat | WB, ELISA | 0.1 mg | |
| Biosynth | F502-130271-01 | 70R-34988 | CDK1 antibody (Thr14) | Rabbit | Polyclonal | Human, Mouse, Rat; Cross: Mouse, Rat. Specific detection of phosphorylated Human: Thr14, Mouse: Thr14, Rat: Thr14 | WB, IF, ELISA | 0.1 mg | |
| Cloud-Clone | T813-122507-01 | PAB888Hu01 | Polyclonal Antibody to Cyclin Dependent Kinase 1 (CDK1) | Rabbit | Polyclonal | Human | WB | 100µl | |
| Cloud-Clone | T813-113553-01 | MAB888Hu22 | Monoclonal Antibody to Cyclin Dependent Kinase 1 (CDK1) | Mouse | Monoclonal | Human | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-122509-01 | PAB888Mu02 | Polyclonal Antibody to Cyclin Dependent Kinase 1 (CDK1) | Rabbit | Polyclonal | Murine | WB | 100µl | |
| Cloud-Clone | T813-122508-01 | PAB888Mu01 | Polyclonal Antibody to Cyclin Dependent Kinase 1 (CDK1) | Rabbit | Polyclonal | Murine | WB; ICC/IF | 100µl | |
| MyBioSource | R247-201584-01 | MBS9210466 | Cdk1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; ELISA | 0.08 mL | |
| MyBioSource | R247-165777-01 | MBS627834 | cdk1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | ELISA; WB; IP | 0.1 mL | |
| MyBioSource | R247-201956-01 | MBS9215243 | Phospho-CDK1 (S39), Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Bovine, Chicken | DB; ELISA; WB; IHC | 0.08 mL | |
| ELK Biotechnology | T376-118698-01 | ES1938 | Cdk1/Cdc2 rabbit pAb | Rabbit | Polyclonal | Human;Mouse;Rat | WB;IHC;IF;ELISA | 50μL | |
| ELK Biotechnology | T376-116120-01 | ES1281 | Cdc2 (phospho Tyr15) rabbit pAb | Rabbit | Polyclonal | Human;Mouse;Rat;Monkey | WB;ELISA | 50μL | |
| MyBioSource | R247-148141-01 | MBS375278 | Cdk1, Monoclonal Antibody | Mouse | Monoclonal | Human, Mouse, Rat, Chicken | FC/FACS; ICC; IF | 0.05 mg | |
| MyBioSource | R247-194122-01 | MBS850715 | CDK1, Antibody | Mouse | Human, Mouse, Rat, Monkey | WB; ELISA | 0.1 mg | ||
| Biosynth | F502-117722-01 | 70R-14947 | CDK1 antibody (Tyr15) | Rabbit | Polyclonal | WB | 100 ul |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
CCNB1
Mitotic Prophase
PLK1
Phosphorylation of Emi1
NUMA1
Mitotic Prophase
PPP2CA
MASTL Facilitates Mitotic Progression
UBE2D1
Phosphorylation of the APC/C
MAPK3
MAPK3 (ERK1) activation
NEK7
Activation of NIMA Kinases NEK9, NEK6, NEK7
YWHAE
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex