CD80이 암호화하는 단백질은 CD28 또는 CTLA-4의 결합으로 활성화되는 막 수용체(membrane receptor)로, 활성화되면 T 세포 증식과 사이토카인(cytokine) 생성을 유도한다. 또한 아데노바이러스 B형 하위군(adenovirus subgroup B)의 수용체로 작용할 수 있으며, 루푸스 신경병증(lupus neuropathy)에 관여할 가능성이 있다.
CD28 dependent PI3K/Akt signalingCD28 dependent Vav1 pathwayCo-inhibition by CTLA4Co-stimulation by CD28Constitutive Signaling by Aberrant PI3K in CancerInterleukin-10 signalingPI5P, PP2A and IER3 Regulate PI3K/AKT SignalingPIP3 activates AKT signaling
rheumatoid arthritispsoriatic arthritisjuvenile idiopathic arthritisimmune system diseasecancerVitiligokidney transplantsystemic lupus erythematosus
The minimum detectable dose of human sCD80 is typically less than 31.25 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
