유전자 개요
CD40LG가 암호화하는 단백질은 T 세포(T cell) 표면에 발현되며, B 세포(B cell) 표면의 CD40과 결합하여 B 세포의 기능을 조절한다. 이 단백질을 만드는 유전자에 결함이 생기면 면역글로불린(immunoglobulin) 클래스 전환이 일어나지 못하며, 이는 고면역글로불린M 증후군(hyper-IgM syndrome)과 연관된다.
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayTNFR2 non-canonical NF-kB pathway
hyper-IgM syndrome type 1X-linked hyper-IgM syndromehyper-IgM syndromeCD40 ligand measurementlymphocyte countgenetic disordercommon variable immunodeficiencyplatelet crit
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) The CD40/CD154 receptor/ligand dyad. · Cell Mol Life Sci (2001)CD40 signaling and plaque instability. · Circ Res (2001)Demethylation of CD40LG on the inactive X in T cells from women with lupus. · J Immunol (2007)
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관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
CD40
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
LTA
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
LTBR
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
TRAF3
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
TNFSF14
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
TNFSF11
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
LTB
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
TNFSF12
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway