CASR — 카탈로그 18건
Gene CASR
NCBI Gene 846
국내 소싱 가능
18건
유전자 개요
이 유전자는 세포막(plasma membrane) G 단백질 연결 수용체(G protein-coupled receptor)를 암호화하며, 순환 칼슘 농도(calcium concentration)의 미세한 변화를 감지합니다. 이 단백질은 해당 정보를 부갑상선 호르몬(parathyroid hormone) 분비 조절 또는 신장 양이온(renal cation) 처리에 관여하는 세포 내 신호 전달 경로와 연결되어, 무기질 이온 항상성(mineral ion homeostasis) 유지에 필수적인 역할을 합니다. 이 유전자의 돌연변이는 가족성 저요세포증 고칼슘혈증(familial hypocalciuric hypercalcemia), 신생아 중증 부갑상선 기능 항진증(neonatal severe hyperparathyroidism), 상염색체 우성 저칼슘혈증(autosomal dominant hypocalcemia)의 원인이 됩니다.
Class C/3 (Metabotropic glutamate/pheromone receptors)G alpha (i) signalling eventsG alpha (q) signalling events
familial hypocalciuric hypercalcemia 1autosomal dominant hypocalcemia 1Familial hypocalciuric hypercalcemia type 1neonatal severe primary hyperparathyroidismFamilial isolated hypoparathyroidismcalcium measurementautosomal dominant hypocalcemiafamilial hypocalciuric hypercalcemia
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion. · Nat Commun (2019)Secretory diarrhoea: mechanisms and emerging therapies. · Nat Rev Gastroenterol Hepatol (2015)Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis. · Nat Commun (2015)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| MyBioSource | R247-212288-01 | MBS9601065 | Calcium Sensing Receptor (CASR), Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IF; ICC; ELISA | 0.1 mL | |
| Biosynth | F502-119026-01 | 70R-16185 | CASR antibody | Rabbit | Polyclonal | Human; Cross: Human, Mouse, Rat | ELISA, WB | 50 ul | |
| Biosynth | F502-128688-01 | 70R-33448 | CASR antibody (Thr888) | Rabbit | Polyclonal | CASR antibody detects endogenous levels of Calcium Sensing Receptor only when phosphorylated at threonine 888; Cross: Mouse, Rat | WB, IF, ELISA | 0.1 mg | |
| Biosynth | F502-128689-01 | 70R-33449 | CASR antibody | Rabbit | Polyclonal | CASR antibody detects endogenous levels of total Calcium Sensing Receptor protein; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Cloud-Clone | T813-123642-01 | PAC414Mu02 | Polyclonal Antibody to Calcium Sensing Receptor (CASR) | Rabbit | Polyclonal | Murine | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-123641-01 | PAC414Mu01 | Polyclonal Antibody to Calcium Sensing Receptor (CASR) | Rabbit | Polyclonal | Murine | IHC | 100µl | |
| MyBioSource | R247-123766-01 | MBS178424 | CASR, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; Immunohistochemistry (IHC) Paraffin | 0.01 mg | |
| MyBioSource | R247-135292-01 | MBS247328 | CASR/Calcium Sensing Receptor, Polyclonal Antibody | Rabbit | Polyclonal | Human, Monkey | Immunohistochemistry (IHC - Paraffin) | 0.05 mg | |
| ELK Biotechnology | T376-121387-01 | ES7763 | CaSR (phospho Thr888) rabbit pAb | Rabbit | Polyclonal | Human;Mouse;Rat | WB;IF;ELISA | 50μL | |
| Enzo Life Sciences | R365-101915-01 | ASB-OAAF00973 | CASR Antibody | Rabbit | 100 µg |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
GRM6
Class C/3 (Metabotropic glutamate/pheromone receptors)
TAS1R3
Class C/3 (Metabotropic glutamate/pheromone receptors)
TAS2R14
Class C/3 (Metabotropic glutamate/pheromone receptors)
TAS2R13
Class C/3 (Metabotropic glutamate/pheromone receptors)
GPRC6A
Class C/3 (Metabotropic glutamate/pheromone receptors)
GRM3
Class C/3 (Metabotropic glutamate/pheromone receptors)
GABBR1
Class C/3 (Metabotropic glutamate/pheromone receptors)
GRM1
Class C/3 (Metabotropic glutamate/pheromone receptors)