C3(보체 성분 3, complement component C3)는 보체 시스템(complement system) 활성화의 중심 역할을 하며, 고전 경로(classical pathway)와 대체 경로(alternative pathway) 모두의 활성화에 반드시 필요합니다. 전구단백질이 단백질 분해를 거쳐 알파·베타 소단위(alpha/beta subunit)로 가공되어 성숙형 단백질을 이루고, 이후 다시 처리되어 항미생물 활성을 지니고 염증을 조절하는 C3a 아나필라톡신(C3a anaphylatoxin) 등 여러 펩타이드 산물을 만들어 냅니다. 이 유전자의 돌연변이는 비정형 용혈성 요독증후군(atypical hemolytic uremic syndrome)과 연령 관련 황반변성(age-related macular degeneration)과 연관되어 있습니다.
Activation of C3 and C5Alternative complement activationG alpha (i) signalling eventsImmunoregulatory interactions between a Lymphoid and a non-Lymphoid cellNeutrophil degranulationPeptide ligand-binding receptorsPost-translational protein phosphorylationPurinergic signaling in leishmaniasis infectionRegulation of Complement cascadeRegulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
atypical hemolytic-uremic syndrome with C3 anomalycomplement component 3 deficiencyage-related macular degenerationmacular degenerationage related macular degeneration 9paroxysmal nocturnal hemoglobinuriadegeneration of macula and posterior poleprotein measurement
The minimum detectable dose of fish C3 is typically less than 12.5 ?g/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest fish C3 concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
