BUB1B — 카탈로그 78건
Gene BUB1B
NCBI Gene 701
국내 소싱 가능
78건
유전자 개요
BUB1B는 방추사 부착 점검점(spindle checkpoint) 기능에 관여하는 키나아제(kinase)를 암호화한다. 이 효소는 동원체(kinetochore)에 위치하며, 후기촉진복합체/사이클로솜(APC/C)을 억제하여 후기(anaphase)의 개시를 지연시키고 염색체가 정확히 분리되도록 한다. 방추사 점검점 기능의 손상은 여러 형태의 암에서 발견된다.
APC-Cdc20 mediated degradation of Nek2AAPC/C:Cdc20 mediated degradation of mitotic proteinsAmplification of signal from unattached kinetochores via a MAD2 inhibitory signalCdc20:Phospho-APC/C mediated degradation of Cyclin AEML4 and NUDC in mitotic spindle formationInactivation of APC/C via direct inhibition of the APC/C complexMitotic PrometaphaseRHO GTPases Activate ForminsResolution of Sister Chromatid CohesionSeparation of Sister Chromatids
mosaic variegated aneuploidy syndromemosaic variegated aneuploidy syndrome 1premature chromatid separation traitneurodegenerative diseasecolorectal cancergenetic disordercolorectal adenocarcinomacolorectal neoplasm
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. · Nature (2011)Deleterious Germline Mutations in Patients With Apparently Sporadic Pancreatic Adenocarcinoma. · J Clin Oncol (2017)Positive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenocarcinoma. · Mol Cancer (2024)
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관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
BUB3
Inactivation of APC/C via direct inhibition of the APC/C complex
UBE2C
Inactivation of APC/C via direct inhibition of the APC/C complex
CDC23
Inactivation of APC/C via direct inhibition of the APC/C complex
UBE2D1
Inactivation of APC/C via direct inhibition of the APC/C complex
UBE2S
Inactivation of APC/C via direct inhibition of the APC/C complex
UBB
APC-Cdc20 mediated degradation of Nek2A
PSMA1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
PSMA3
Cdc20:Phospho-APC/C mediated degradation of Cyclin A