BECN1 — 카탈로그 53건
Gene BECN1
NCBI Gene 8678
국내 소싱 가능
53건
유전자 개요
BECN1은 기아 상태에서 유도되는 분해성 이화 과정인 오토파지(autophagy)을 조절하는 단백질을 암호화한다. 이 단백질은 소포 수송(vesicle trafficking)을 매개하는 포스파티딜이노시톨-3-인산화효소(phosphatidylinositol-3-kinase, PI3K) 복합체의 구성 성분으로, 종양 형성, 신경퇴행, 세포자멸사(apoptosis) 등 여러 세포 과정에 관여하는 것으로 여겨진다. 대체 스플라이싱(alternative splicing)을 통해 여러 전사체 변이체가 생성된다.
Antigen Presentation: Folding, assembly and peptide loading of class I MHCISG15 antiviral mechanismMacroautophagyRSV-host interactionsSARS-CoV-2 activates/modulates innate and adaptive immune responsesTranslation of Replicase and Assembly of the Replication Transcription ComplexTranslation of Replicase and Assembly of the Replication Transcription ComplexUb-specific processing proteases
neurodegenerative diseaseCOVID-19severe acute respiratory syndromelysosomal storage diseasehigh density lipoprotein cholesterol measurementBMI-adjusted waist circumferencelow density lipoprotein cholesterol measurementphospholipids:total lipids ratio
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation. · Cell Death Dis (2019)AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System X(c)(-) Activity. · Curr Biol (2018)IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation. · Nat Commun (2021)
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관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
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Translation of Replicase and Assembly of the Replication Transcription Complex
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Translation of Replicase and Assembly of the Replication Transcription Complex
UVRAG
Translation of Replicase and Assembly of the Replication Transcription Complex
CHMP4B
Translation of Replicase and Assembly of the Replication Transcription Complex
BCAP31
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ATG14
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B2M
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HSPA5
Antigen Presentation: Folding, assembly and peptide loading of class I MHC