BAD — 카탈로그 99건
Gene BAD
NCBI Gene 572
유전자 개요
BAD는 프로그램된 세포 사멸을 조절하는 BCL-2 패밀리(BCL-2 family)에 속하는 단백질을 암호화한다. 이 단백질은 BCL-xL(B-cell lymphoma-extra large) 및 BCL-2와 이종이량체(heterodimer)를 형성해 이들의 사멸 억제 활성을 역전시킴으로써 세포자멸사(apoptosis)를 양성 조절한다. 세포자멸사 촉진 활성은 인산화(phosphorylation)를 통해 조절되며, 단백질 키나아제(kinase)인 AKT와 MAP kinase, 그리고 단백질 인산가수분해효소(phosphatase)인 칼시뉴린(calcineurin)이 이 조절에 관여하는 것으로 확인되었다.
AKT phosphorylates targets in the cytosolActivation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 membersConstitutive Signaling by AKT1 E17K in CancerNRAGE signals death through JNK
neurodegenerative diseaseMODYAlzheimer diseaseneoplasmtriple-negative breast cancertype 1 diabetes mellitushigh density lipoprotein cholesterol measurementheel bone mineral density
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) α-Defensins in human innate immunity. · Immunol Rev (2012)Breaking bad news. · Am Fam Physician (2001)Bad phosphorylation as a target of inhibition in oncology. · Cancer Lett (2018)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| Enzo Life Sciences | R365-100008-01 | AAP-020 | Bad polyclonal antibody | Goat | Polyclonal | Weakly cross-reacts with dog and chicken Bad. | ELISA, IHC, WB | 50 µg | |
| Abbexa | F158-115533-01 | abx328450 | Bcl2-Associated Agonist Of Cell Death (BAD) Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | ELISA, WB, IHC | 50 µg | |
| Abbexa | F158-101702-01 | abx031832 | Bad (pS75) Antibody | Rabbit | Polyclonal | Human | ELISA, WB, IHC | 80 µl | |
| Abbexa | F158-100511-01 | abx011755 | Bcl2-Associated Agonist Of Cell Death (BAD) Antibody | Rabbit | Polyclonal | Human | ELISA, WB | 100 µg | |
| Abbexa | F158-105097-01 | abx119211 | BAD (pS136) Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB, IHC | 10 µg | |
| Abbexa | F158-115812-01 | abx333271 | BAD (pS91 / 128) Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | ELISA, WB, IHC | 100 µl | |
| Abbexa | F158-105096-01 | abx119210 | BAD (pS112) Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB, IHC | 10 µg | |
| Abbexa | F158-101703-01 | abx031833 | Bad (pS99) Antibody | Rabbit | Polyclonal | Human | ELISA, IHC, IF/ICC, DB | 80 µl | |
| Abbexa | F158-115704-01 | abx329911 | Bcl2-Associated Agonist Of Cell Death (BAD) Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Monkey | ELISA, WB, IHC | 50 µg | |
| Abbexa | F158-110724-01 | abx230784 | Bcl2-Associated Agonist Of Cell Death (BAD) Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | ELISA, WB, IHC, IF/ICC | 100 µg | |
| Abbexa | F158-101369-01 | abx027239 | Bcl2-Associated Agonist Of Cell Death (BAD) Antibody | Rabbit | Polyclonal | Human | ELISA, WB, IHC | 80 µl | |
| Abbexa | F158-115497-01 | abx328193 | Bcl2-Associated Agonist Of Cell Death (BAD) Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | ELISA, WB, IHC | 50 µg | |
| Abbexa | F158-115306-01 | abx326401 | Bcl2-Associated Agonist Of Cell Death (BAD) Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | ELISA, IHC | 50 µg | |
| Abbexa | F158-105422-01 | abx128971 | Bcl2 Associated Death Promoter (BAD) Antibody | Rabbit | Polyclonal | Human | WB, IHC | 100 µl | |
| Abbexa | F158-101700-01 | abx031830 | Bad (pS118) Antibody | Rabbit | Polyclonal | Human | ELISA, WB, IHC | 80 µl | |
| Abbexa | F158-101796-01 | abx032255 | BAD (pS96) Antibody | Rabbit | Polyclonal | Mouse | ELISA, DB | 80 µl | |
| Abbexa | F158-101701-01 | abx031831 | Bad (pS134) Antibody | Rabbit | Polyclonal | Human | ELISA, WB, IHC | 80 µl | |
| Abbexa | F158-100131-01 | abx001341 | Bcl2-Associated Agonist Of Cell Death (BAD) Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | ELISA, WB, IF/ICC | 20 µl | |
| Abbexa | F158-115660-01 | abx329564 | Bcl2-Associated Agonist Of Cell Death (BAD) Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | ELISA, WB, IHC, IF/ICC | 50 µg | |
| MyBioSource | R247-212499-01 | MBS9602017 | BAD, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; IF; ICC; ELISA | 0.1 mL | |
| MyBioSource | R247-168090-01 | MBS6370906 | BAD, Polyclonal Antibody | Rabbit | Polyclonal | Human | WB | 0.1 mL | |
| MyBioSource | R247-168089-01 | MBS6370905 | BAD, Polyclonal Antibody | Rabbit | Polyclonal | Human | WB | 0.1 mL | |
| MyBioSource | R247-211177-01 | MBS9502682 | BAD, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; IF; ELISA | 0.05 mL | |
| MyBioSource | R247-138256-01 | MBS2556105 | BAD, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | IHC | 0.06 mL | |
| MyBioSource | R247-119542-01 | MBS151457 | BAD, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | ELISA; WB; IHC; IF | 0.1 mg | |
| MyBioSource | R247-212498-01 | MBS9602016 | BAD, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; IF; ICC; ELISA | 0.1 mL | |
| MyBioSource | R247-168093-01 | MBS6370913 | BAD, Polyclonal Antibody | Rabbit | Polyclonal | Human | WB | 0.1 mL | |
| MyBioSource | R247-212322-01 | MBS9601240 | BAD, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; IF; ICC; ELISA | 0.1 mL | |
| MyBioSource | R247-212323-01 | MBS9601241 | BAD, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; IF; ICC; ELISA | 0.1 mL | |
| MyBioSource | R247-168088-01 | MBS6370904 | BAD, Polyclonal Antibody | Rabbit | Polyclonal | Human | WB | 0.1 mL | |
| MyBioSource | R247-168087-01 | MBS6370903 | BAD, Polyclonal Antibody | Rabbit | Polyclonal | Human | WB | 0.1 mL | |
| MyBioSource | R247-168091-01 | MBS6370907 | BAD, Polyclonal Antibody | Rabbit | Polyclonal | Human | WB | 0.1 mL | |
| MyBioSource | R247-213567-01 | MBS9607141 | BAD, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; IF; ICC; ELISA | 0.1 mL | |
| Biosynth | F502-128680-01 | 70R-33440 | BAD antibody (Ser134) | Rabbit | Polyclonal | BAD antibody detects endogenous levels of BAD only when phosphorylated at serine 134; Cross: Mouse, Rat | WB, IHC, IF, ELISA | 0.1 mg | |
| Biosynth | F502-131262-01 | 70R-36187 | BAD antibody (Ser155) | Rabbit | Polyclonal | BAD antibody (Ser155) detects endogenous levels of BAD only when phosphorylated at serine 155; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-128677-01 | 70R-33438 | BAD antibody (Ser91/128) | Rabbit | Polyclonal | BAD antibody detects endogenous levels of BAD only when phosphorylated at serine 91/ serine 128; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-131078-01 | 70R-35957 | BAD antibody | Rabbit | Polyclonal | BAD antibody detects endogenous levels of total BAD protein; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-132431-01 | 70R-37504 | BAD antibody | Rabbit | Polyclonal | Human; Cross: Mouse, Rat | WB, IHC | 0.1 mg | |
| Biosynth | F502-118774-01 | 70R-15956 | BAD antibody | Rabbit | Polyclonal | Human; Cross: Human, Mouse, Rat | ELISA, WB | 50 ul | |
| Biosynth | F502-131350-01 | 70R-36296 | BAD antibody | Rabbit | Polyclonal | BAD antibody detects endogenous levels of total BAD protein; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-132429-01 | 70R-37502 | BAD antibody | Rabbit | Polyclonal | Human; Cross: Mouse, Rat | WB, IHC | 0.1 mg | |
| Biosynth | F502-131751-01 | 70R-36795 | BAD antibody (Ser136) | Rabbit | Polyclonal | BAD antibody (Ser136) detects endogenous levels of BAD only when phosphorylated at serine136; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-131251-01 | 70R-36173 | BAD antibody (Ser112) | Rabbit | Polyclonal | BAD antibody (Ser112) detects endogenous levels of BAD only when phosphorylated at serine 112; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-132430-01 | 70R-37503 | BAD antibody | Rabbit | Polyclonal | Human; Cross: Mouse, Rat | WB, IHC | 0.1 mg | |
| Biosynth | F502-132048-01 | 70R-37149 | BAD antibody (Ser136) | Rabbit | Polyclonal | BAD antibody (Ser136) detects endogenous levels of BAD only when phosphorylated at Serine 136; Cross: Mouse, Rat | IHC | 0.1 mg | |
| Biosynth | F502-128678-01 | 70R-33439 | BAD antibody | Rabbit | Polyclonal | BAD antibody detects endogenous levels of total BAD protein; Cross: Mouse, Rat | IHC, ELISA | 0.1 mg | |
| Biosynth | F502-132050-01 | 70R-37150 | BAD antibody (Ser155) | Rabbit | Polyclonal | BAD antibody (Ser155) detects endogenous levels of BAD only when phosphorylated at serine 155; Cross: Mouse, Rat | WB, IHC | 0.1 mg | |
| Biosynth | F502-126530-01 | 70R-31074 | BAD antibody | Rabbit | Polyclonal | BAD antibody detects endogenous levels of fragment of activated BAD resulting from cleavage adjacent to Asp71; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-132047-01 | 70R-37148 | BAD antibody (Ser112) | Rabbit | Polyclonal | BAD antibody (Ser112) detects endogenous levels of BAD only when phosphorylated at serine 112; Cross: Mouse, Rat | WB, IHC | 0.1 mg | |
| Biosynth | F502-128681-01 | 70R-33441 | BAD antibody | Rabbit | Polyclonal | BAD antibody detects endogenous levels of total BAD protein; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-130357-01 | 70R-35096 | BAD antibody | Rabbit | Polyclonal | BAD antibody detects endogenous levels of total BAD protein; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Cloud-Clone | T813-123533-01 | PAC337Hu01 | Polyclonal Antibody to Bcl2 Associated Death Promoter (BAD) | Rabbit | Polyclonal | Human | WB; IHC | 100µl | |
| MyBioSource | R247-150761-01 | MBS435295 | Bad, Monoclonal Antibody | Rabbit | Monoclonal | Human, Mouse, Rat | WB; IHC; ICC; IF; IP; FC/FACS | 0.05 mL | |
| MyBioSource | R247-137743-01 | MBS2539525 | Bad, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; ELISA | 0.03 mL | |
| MyBioSource | R247-214440-01 | MBS9611215 | Bad, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Bovine, Dog, Sheep, Horse | WB; EIA | 0.05 mL | |
| MyBioSource | R247-207890-01 | MBS9404157 | BAD, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC | 0.05 mL | |
| MyBioSource | R247-201390-01 | MBS9207687 | Phospho-Bad (S99), Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | IF; DB; ELISA; IHC | 0.08 mL | |
| MyBioSource | R247-214353-01 | MBS9610789 | Bad, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Bovine, Dog, Sheep, Horse | WB; IHC; EIA | 0.05 mL | |
| MyBioSource | R247-137755-01 | MBS2539809 | Bad, Polyclonal Antibody | Rabbit | Polyclonal | Mouse, Rat | WB; IHC; ELISA | 0.02 mL | |
| MyBioSource | R247-151580-01 | MBS440003 | Bad, Polyclonal Antibody | Rabbit | Polyclonal | Mouse, Rat | WB; IHC | 0.2 mg | |
| MyBioSource | R247-200954-01 | MBS9201848 | Phospho-Bad (S134), Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | ELISA; IHC; WB | 0.08 mL | |
| MyBioSource | R247-177134-01 | MBS713687 | BCL2-associated agonist of cell death (BAD), Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | ELISA; WB | 0.1 mL | |
| MyBioSource | R247-201312-01 | MBS9206541 | Bad BH3 Domain, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse | WB; ELISA; IHC; FC/FACS | 0.08 mL | |
| MyBioSource | R247-191048-01 | MBS8241382 | BAD, Polyclonal Antibody | Rabbit | Polyclonal | Human, Monkey | WB; IHC; IF; ICC | 0.03 mL | |
| MyBioSource | R247-207952-01 | MBS9405193 | BAD, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse | WB; IHC | 0.05 mL | |
| MyBioSource | R247-113469-01 | MBS127473 | BAD, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; IF | 0.02 mL | |
| Biosynth | F502-109054-01 | 20R-2244 | BAD antibody | Rabbit | Mouse | IHC, WB | 0.05 mg | ||
| Biosynth | F502-109053-01 | 20R-2243 | BAD antibody | Rabbit | Human; Cross: Human, Mouse, Rat | IHC, WB | 0.05 mg | ||
| Biosynth | F502-109055-01 | 20R-2245 | BAD antibody | Rabbit | Human; Cross: Human, Mouse, Rat | IHC, WB | 0.05 mg | ||
| Biosynth | F502-108745-01 | 20R-1929 | BAD antibody | Rabbit | Mouse | IHC, WB | 0.05 mg | ||
| Biosynth | F502-108744-01 | 20R-1928 | BAD antibody | Rabbit | Human; Cross: Human, Mouse, Rat | IHC, WB | 0.05 mg | ||
| MyBioSource | R247-112678-01 | MBS125040 | Bad-S99, Antibody | Rabbit | Human | WB; IHC | 0.02 mL | ||
| MyBioSource | R247-112696-01 | MBS125138 | Bad-S118, Antibody | Rabbit | Human | WB | 0.02 mL | ||
| MyBioSource | R247-112731-01 | MBS125253 | Bad-S75, Antibody | Rabbit | Human, Mouse, Rat | WB | 0.02 mL | ||
| Biosynth | F502-138710-01 | 70R-7834 | BAD antibody | Rabbit | Polyclonal | Human; Cross: Predicted: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit | WB | 100 ul | |
| Biosynth | F502-136003-01 | 70R-51460 | BAD antibody | Rabbit | Polyclonal | Recognizes endogenous levels of BAD protein; Cross: Mouse, Rat, Bovine | WB, IHC | 100 ul | |
| ELK Biotechnology | T376-121060-01 | ES6877 | Bad (phospho Ser134) rabbit pAb | Rabbit | Polyclonal | Human;Mouse;Rat | WB;IHC;IF;ELISA | 50μL | |
| MyBioSource | R247-194271-01 | MBS851529 | BAD, Antibody | Human, Mouse, Rat | IHC; ELISA | 0.1 mg | |||
| MyBioSource | R247-194391-01 | MBS851815 | BAD, Antibody | Human, Mouse, Rat | WB; IHC; ELISA | 0.1 mg | |||
| MyBioSource | R247-196623-01 | MBS859261 | BAD, Antibody | Human, Mouse, Rat | WB; IHC; IF; ELISA | 0.1 mg | |||
| MyBioSource | R247-196073-01 | MBS856840 | BAD, Antibody | Human, Mouse, Rat | WB; IHC | 0.05 mg | |||
| MyBioSource | R247-195451-01 | MBS854961 | BAD, Antibody | Mouse, Rat | WB; IHC; ELISA | 0.1 mg | |||
| MyBioSource | R247-196172-01 | MBS857069 | BAD, Antibody | Human, Mouse, Rat | WB; IHC | 0.05 mg |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
BCL2
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
BID
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
AKT1
AKT phosphorylates targets in the cytosol
AKT2
AKT phosphorylates targets in the cytosol
AKT3
AKT phosphorylates targets in the cytosol
BCL2L11
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
STAT3
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
BCL2L1
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members