AXIN1 — 카탈로그 13건
Gene AXIN1
NCBI Gene 8312
취급 제조사 2곳
국내 소싱 가능
13건
APC truncation mutants have impaired AXIN bindingAXIN missense mutants destabilize the destruction complexBeta-catenin phosphorylation cascadeCTNNB1 S33 mutants aren't phosphorylatedCTNNB1 S37 mutants aren't phosphorylatedCTNNB1 S45 mutants aren't phosphorylatedCTNNB1 T41 mutants aren't phosphorylatedDegradation of AXINDegradation of beta-catenin by the destruction complexDeletions in the AXIN1 gene destabilize the destruction complex
hepatocellular carcinomacraniometadiaphyseal osteosclerosis with hip dysplasiacancercaudal duplicationchronic myelogenous leukemiaHepatobiliary Neoplasmlung carcinomaesophageal adenocarcinoma
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. · Nat Genet (2015)Genetic Landscape and Biomarkers of Hepatocellular Carcinoma. · Gastroenterology (2015)WNT/β-catenin Pathway Activation Correlates with Immune Exclusion across Human Cancers. · Clin Cancer Res (2019)
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관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
PPP2CA
Truncations of AMER1 destabilize the destruction complex
GSK3B
Truncations of AMER1 destabilize the destruction complex
CSNK1A1
Truncations of AMER1 destabilize the destruction complex
CTNNB1
CTNNB1 S33 mutants aren't phosphorylated
RUNX1
RUNX1 regulates estrogen receptor mediated transcription
ESR1
RUNX1 regulates estrogen receptor mediated transcription
FOXP3
RUNX1 regulates transcription of genes involved in WNT signaling
RSPO3
RUNX1 regulates transcription of genes involved in WNT signaling