ARAF — 카탈로그 17건
Gene ARAF
NCBI Gene 369
국내 소싱 가능
17건
유전자 개요
ARAF 유전자는 단백질 세린/트레오닌 키나아제(protein serine/threonine kinase) 활성을 가능하게 한다. 이 유전자는 세포 사멸 과정의 음성 조절, mTOR 신호 전달 조절, 단백질 대사 과정 조절에 관여한다. 세포질 및 미토콘드리아(mitochondrion) 내에서 활성을 보일 것으로 예측되며, 고등급 교종(high grade glioma)의 바이오마커이다.
Gain-of-function MRAS complexes activate RAF signalingMAP2K and MAPK activationNegative regulation of MAPK pathwayParadoxical activation of RAF signaling by kinase inactive BRAFRAF activationSHOC2 M1731 mutant abolishes MRAS complex functionSignaling by BRAF and RAF1 fusionsSignaling by RAF1 mutantsSignaling by high-kinase activity BRAF mutantsSignaling by moderate kinase activity BRAF mutants
cancerhypertrophic cardiomyopathyCostello syndromeNoonan syndromelymphatic malformation 12low grade gliomacolorectal adenocarcinomalung adenocarcinoma
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Consensus recommendations for the diagnosis and clinical management of Rosai-Dorfman-Destombes disease. · Blood (2018)RAF-MEK-ERK pathway in cancer evolution and treatment. · Semin Cancer Biol (2022)Efficacy of MEK inhibition in patients with histiocytic neoplasms. · Nature (2019)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| Biosynth | F502-128226-01 | 70R-32633 | ARAF antibody (Ser299) | Rabbit | Polyclonal | ARAF antibody detects endogenous levels of ARAF only when phosphorylated at serine 299; Cross: Mouse, Rat | IHC, ELISA | 0.1 mg | |
| Biosynth | F502-127083-01 | 70R-31583 | ARAF antibody | Rabbit | Polyclonal | ARAF antibody detects endogenous levels of total ARAF protein; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-133736-01 | 70R-49391 | ARAF antibody | Rabbit | Polyclonal | Recognizes endogenous levels of A-RAF protein; Cross: Mouse, Rat, Bovine, Pig, Sheep | WB | 100 ul | |
| Biosynth | F502-128600-01 | 70R-33365 | ARAF antibody | Rabbit | Polyclonal | ARAF antibody detects endogenous levels of total ARAF protein; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-115887-01 | 70R-12576 | ARAF antibody | Rabbit | Polyclonal | Human, Mouse | IF, ICC, IHC-P, WB | 100 ul | |
| Biosynth | F502-131767-01 | 70R-36815 | ARAF antibody | Rabbit | Polyclonal | Human | ELISA, IHC | 0.1 mg | |
| Biosynth | F502-128599-01 | 70R-33364 | ARAF antibody (Tyr301/302) | Rabbit | Polyclonal | ARAF antibody detects endogenous levels of ARAF only when phosphorylated at tyrosine 301/tyrosine 302; Cross: Mouse, Rat | WB, IHC, IF, ELISA | 0.1 mg | |
| MyBioSource | R247-214402-01 | MBS9611002 | A-RAF, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Rabbit, Bovine, Dog, Pig, Sheep, Zebrafish, Horse | WB; EIA | 0.05 mL | |
| MyBioSource | R247-156130-01 | MBS5311801 | ARAF, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse | IF; ICC; Immunohistochemistry (IHC) Paraffin; WB | 0.1 mL | |
| MyBioSource | R247-208298-01 | MBS9410653 | ARAF, Polyclonal Antibody | Rabbit | Polyclonal | Human | WB; IHC; IF | 0.1 mL | |
| MyBioSource | R247-214303-01 | MBS9610576 | A-RAF, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Rabbit, Bovine, Dog, Pig, Sheep, Zebrafish, Horse | WB; EIA | 0.05 mL | |
| Biosynth | F502-136932-01 | 70R-5718 | ARAF antibody | Rabbit | Polyclonal | Human; Cross: Predicted: Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit, Sheep | WB | 100 ul | |
| ELK Biotechnology | T376-120721-01 | ES5953 | A-Raf (phospho Tyr302) rabbit pAb | Rabbit | Polyclonal | Human;Mouse;Rat | WB;IHC;IF;ELISA | 50μL | |
| ELK Biotechnology | T376-120722-01 | ES5955 | A-Raf rabbit pAb | Rabbit | Polyclonal | Human;Mouse;Rat;Monkey | WB;ELISA | 50μL | |
| MyBioSource | R247-196524-01 | MBS858384 | A-RAF, Antibody | Human, Mouse, Rat | WB; IHC; ELISA | 0.1 mg |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.