ADAM10 — 카탈로그 73건
Gene ADAM10
NCBI Gene 102
국내 소싱 가능
73건
유전자 개요
ADAM10은 잠재적 부착(adhesion) 도메인과 단백질 분해효소(protease) 도메인을 모두 갖춘 독특한 구조의 세포 표면 단백질로, ADAM 패밀리(ADAM family)에 속한다. TNF-alpha와 E-cadherin을 비롯한 여러 단백질을 절단하며, 대체 스플라이싱(alternate splicing)을 통해 유사한 가공 과정을 거칠 수 있는 서로 다른 단백질을 암호화하는 여러 전사체 변이(transcript variants)가 생성된다.
Activated NOTCH1 Transmits Signal to the NucleusAmyloid fiber formationCollagen degradationConstitutive Signaling by NOTCH1 HD Domain MutantsConstitutive Signaling by NOTCH1 HD+PEST Domain MutantsConstitutive Signaling by NOTCH1 PEST Domain MutantsConstitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation MutantDegradation of the extracellular matrixEPH-ephrin mediated repulsion of cellsNOTCH2 Activation and Transmission of Signal to the Nucleus
reticulate acropigmentation of KitamuraAlzheimer disease 18Alzheimer diseasehigh density lipoprotein cholesterol measurementbody fat percentagefamily history of Alzheimer’s diseasebody mass indexultraviolet radiation exposure measurement
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) The metalloproteinase ADAM10: A useful therapeutic target? · Biochim Biophys Acta Mol Cell Res (2017)Alpha-secretase as a therapeutic target. · Curr Alzheimer Res (2007)Proteolytically active ADAM10 and ADAM17 carried on membrane microvesicles in human abdominal aortic aneurysms. · Thromb Haemost (2015)
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관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
JAG1
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
DLL4
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
JAG2
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
DLL1
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
ADAM17
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
NOTCH1
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
PSEN1
NOTCH4 Activation and Transmission of Signal to the Nucleus
PSENEN
NOTCH4 Activation and Transmission of Signal to the Nucleus