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MyBioSource
MBS9232231 — Glargine Insulin, Polyclonal Antibody
Target Insulin glargine, marketed under the names Lantus, among others, is a long-acting basal insulin analogue, given once daily to help control the blood sugar level of those with diabetes. Insulin glargine has a substitution of glycine for asparagine at N21 (Asn21) and two arginines added to the carboxy terminal of B chain. The arginine amino acids shift the isoelectric point from a pH of 5.4 to 6.7, making the molecule more soluble at an acidic pH and less soluble at physiological pH. The isoelectric shift also allows for the subcutaneous injection of a clear solution. The glycine substitution prevents deamidation of the acid-sensitive asparagine at acidic pH. In the neutral subcutaneous space, higher-order aggregates form, resulting in a slow, peakless dissolution and absorption of insulin from the site of injection. It can achieve a peakless level for at least 24 hours. Molecular formula: C267H404N72O78S6 Molecular weight: 6063
Host Guinea Pig
Clonality Polyclonal
Conjugate N/A
Reactivity Guinea Pig, Pig
Assay N/A
Application ELISA
Specifications
| Cat No | R247-202432-01 0.1 mL |
|---|---|
| Mfr No | MBS9232231 |
| 제조사 | MyBioSource |
| 제품명 | Glargine Insulin, Polyclonal Antibody |
| Sub type | Primary |
| Target | Insulin glargine, marketed under the names Lantus, among others, is a long-acting basal insulin analogue, given once daily to help control the blood sugar level of those with diabetes. Insulin glargine has a substitution of glycine for asparagine at N21 (Asn21) and two arginines added to the carboxy terminal of B chain. The arginine amino acids shift the isoelectric point from a pH of 5.4 to 6.7, making the molecule more soluble at an acidic pH and less soluble at physiological pH. The isoelectric shift also allows for the subcutaneous injection of a clear solution. The glycine substitution prevents deamidation of the acid-sensitive asparagine at acidic pH. In the neutral subcutaneous space, higher-order aggregates form, resulting in a slow, peakless dissolution and absorption of insulin from the site of injection. It can achieve a peakless level for at least 24 hours. Molecular formula: C267H404N72O78S6 Molecular weight: 6063 |
| Host | Guinea Pig |
| Reactivity | Guinea Pig, Pig |
| Application | ELISA |
| Clonality | Polyclonal |
| 보관 | -20°C |
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